Abstract
Abstract: A total of 25 samples of water being used by pharmaceutical industries in Bangladesh for drug manufacturing were investigated for alpha/beta activity. The samples were collected from 7 different pharmaceutical industries in 2020–2022. EPA 900 method was followed for sample collection and preparation for measuring the gross alpha and beta activity using a ZnS scintillation detector. The gross alpha and beta activity ranged from 0.0018 ± 0.0007 to 0.0091 ± 0.0009 Bq/L with a mean value of 0.0039 ± 0.0007 Bq/L and from 0.0304 ± 0.0213 to 0.1835 ± 0.0214 Bq/L with an average value of 0.0948 ± 0.0213 Bq/L, respectively. The annual effective dose (AED) for the gross alpha and beta activity ranged from 0.0005 ± 0.0002 to 0.0024 ± 0.0002 mSv/year with a mean of 0.0010 ± 0.0002 mSv/year and from 0.0079 ± 0.0056 to 0.0480 ± 0.0056 mSv/year with a mean of 0.0248 ± 0.0056 mSv/year, respectively. Monitoring these parameters in pharmaceutical water should be recommended as a critical quality control measure to maintain the safety and integrity of drug products.
| Original language | English |
|---|---|
| Pages (from-to) | 954-961 |
| Number of pages | 8 |
| Journal | Radiochemistry |
| Volume | 67 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2025 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 9 Industry, Innovation, and Infrastructure
Keywords
- gross alpha activity
- gross beta activity
- pharmaceutical company
- scintillation detector
- water
- World Health Organization
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