Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs

Popat Mohite; Shruti Sule; Anil Pawar; Hanan M. Alharbi; Swastika Maitra; Vetriselvan Subramaniyan; Vinoth Kumarasamy; Daniel Ejim Uti; Celestine O. Ogbu; Simon Inedu Oodo; Ajoy Kumer; Ayodeji Oluwafemi Idowu; Okechukwu N.N. Okoye

doi:10.1038/s41598-024-73760-7

Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs

Popat Mohite
, Shruti Sule
, Anil Pawar
, Hanan M. Alharbi
, Swastika Maitra
, Vetriselvan Subramaniyan
, Vinoth Kumarasamy
, Daniel Ejim Uti
, Celestine O. Ogbu
, Simon Inedu Oodo
, Ajoy Kumer
, Ayodeji Oluwafemi Idowu
, Okechukwu N.N. Okoye

St. John Institute of Pharmacy and Research
MES’s College of Pharmacy
Umm Al-Qura University
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)
Columbia University
Universiti Kebangsaan Malaysia
Federal University of Health Sciences
International University of Business, Agriculture and Technology
Prince of Songkla University
Evangel University Akaeze

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability.

Original language	English
Article number	27724
Journal	Scientific Reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41598-024-73760-7
Publication status	Published - Dec 2024
Externally published	Yes

Keywords

Cosurfactant, solubility
Ornidazole self-nano emulsifying system
Surfactant

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10.1038/s41598-024-73760-7

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Mohite, P., Sule, S., Pawar, A., Alharbi, H. M., Maitra, S., Subramaniyan, V., Kumarasamy, V., Uti, D. E., Ogbu, C. O., Oodo, S. I., Kumer, A., Idowu, A. O., & Okoye, O. N. N. (2024). Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs. Scientific Reports, 14(1), Article 27724. https://doi.org/10.1038/s41598-024-73760-7

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title = "Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs",

abstract = "This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability.",

keywords = "Cosurfactant, solubility, Ornidazole self-nano emulsifying system, Surfactant",

author = "Popat Mohite and Shruti Sule and Anil Pawar and Alharbi, \{Hanan M.\} and Swastika Maitra and Vetriselvan Subramaniyan and Vinoth Kumarasamy and Uti, \{Daniel Ejim\} and Ogbu, \{Celestine O.\} and Oodo, \{Simon Inedu\} and Ajoy Kumer and Idowu, \{Ayodeji Oluwafemi\} and Okoye, \{Okechukwu N.N.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

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doi = "10.1038/s41598-024-73760-7",

language = "English",

volume = "14",

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Mohite, P, Sule, S, Pawar, A, Alharbi, HM, Maitra, S, Subramaniyan, V, Kumarasamy, V, Uti, DE, Ogbu, CO, Oodo, SI, Kumer, A, Idowu, AO & Okoye, ONN 2024, 'Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs', Scientific Reports, vol. 14, no. 1, 27724. https://doi.org/10.1038/s41598-024-73760-7

TY - JOUR

T1 - Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs

AU - Mohite, Popat

AU - Sule, Shruti

AU - Pawar, Anil

AU - Alharbi, Hanan M.

AU - Maitra, Swastika

AU - Subramaniyan, Vetriselvan

AU - Kumarasamy, Vinoth

AU - Uti, Daniel Ejim

AU - Ogbu, Celestine O.

AU - Oodo, Simon Inedu

AU - Kumer, Ajoy

AU - Idowu, Ayodeji Oluwafemi

AU - Okoye, Okechukwu N.N.

PY - 2024/12

Y1 - 2024/12

N2 - This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability.

AB - This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability.

KW - Cosurfactant, solubility

KW - Ornidazole self-nano emulsifying system

KW - Surfactant

UR - https://www.scopus.com/pages/publications/85209379990

U2 - 10.1038/s41598-024-73760-7

DO - 10.1038/s41598-024-73760-7

M3 - Article

C2 - 39532892

AN - SCOPUS:85209379990

SN - 2045-2322

VL - 14

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 27724

ER -

Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs

Abstract

Keywords

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